Author

Abdulrahman El Sayed

International Institute of Molecular Mechanisms and Machines Polish Academy of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Abdelhalim AzziiD· 4 shared Remigiusz Adam SerwaiD· 2 shared Maciej ZakrzewskiiD· 1 shared Monika KluzekiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

4 top collaborators · 5 mutual co-author links

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4 shared papersBiochemistry

Abdelhalim AzziORCID

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4 papers

Recent·Most cited

SHIP2-SRC-β-catenin signaling axis sustains thymidylate synthase expression and promotes fluoropyrimidine resistance.

Abdulrahman El Sayed, Abdelhalim Azzi

This study identifies SHIP2 as a regulator of TYMS expression and fluoropyrimidine resistance in breast cancer by promoting β-catenin nuclear accumulation and SRC activity.

bioRxiv · Jun 9, 2026 · PreprintCancer Biology

SHIP2 oligomeric states and activity regulate cellular responses to sodium arsenate-induced stress granule dynamics.

Abdulrahman El Sayed, Abdelhalim Azzi

This study shows SHIP2 exists as a homodimer in cells, and its oligomerization affects interactome and cellular response to sodium arsenate-induced stress granule dynamics.

bioRxiv · May 27, 2026 · PreprintBiochemistry

Lysosomal accumulation of Masitinib alters autophagy via pH-dependent trapping.

Abdulrahman El Sayed, Monika Kluzek, Remigiusz Adam Serwa, Abdelhalim Azzi

This study shows that masitinib accumulates in lysosomes via pH-dependent trapping, disrupting autophagy by impairing lysosomal acidification.

European Journal of Pharmacology · Apr 19, 2026Peer-reviewedPharmacology & Toxicology

Mechanistic Insights into TYSM Protein Regulation by mTORC2 in Response to Chemotherapy.

Abdulrahman El Sayed, Maciej Zakrzewski, Remigiusz Adam Serwa, Abdelhalim Azzi

The paper shows that TYMS protein levels change in a biphasic manner after 5-FU treatment, driven by translation rather than transcription, and identifies SIN1 as a key regulator.

bioRxiv · May 6, 2025 · PreprintBiochemistry