Loss of PIK3CA allows in vitro growth but not in vivo progression of KRAS mutant lung adenocarcinoma in a syngeneic orthotopic implantation model
Abigail Booth, Giuseppe Caso, Barbara Rosati, Ya-Ping Jiang, Wei-Xing zong, Richard Z. Lin, Harold Bien
This study shows that PIK3CA is not required for in vitro growth of KRAS mutant lung cancer cells but is essential for in vivo tumor progression in a syngeneic mouse model.
Cells · Mar 12, 2026Peer-reviewedCancer Biology