Distinct cellular and transcriptional mechanisms mediate an antioxidant therapeutic response in 22q11-deleted upper layer cortical projection neurons
Shah Rukh, Daniel W. Meechan, Abra Roberts, Connor Siggins, Zachary D. Erwin, Thomas Michael Maynard, Anthony‐Samuel LaMantia
This study shows NAC treatment improves LgDel 22q11.2 deletion syndrome mouse cortical neurons' growth and connectivity without restoring wild-type gene expression or cell states.
bioRxiv · Dec 8, 2025 · PreprintNeuroscience