Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory
Umesh Gangishetti, Sergio Ramírez-Pérez, Kyle Jones, Abul Arif, Hicham Drissi, Pallavi Bhattaram
The paper identifies sustained gene expression and chromatin changes in fibroblast-like synoviocytes under chronic TNF exposure, revealing long-term inflammatory memory through persistent activation and repression of specific signaling pathways.
Scientific Reports · Nov 20, 2020Peer-reviewedMolecular Biology