Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery
Junedh Amrute, Ada Zhu, Yun-Ling Pai, Melissa Hector-Greene, Yuqian An, Kenji Rowell Kim, Maya U. Sheth, Arun Padmanabhan, Clara Youngna Lee, Tracy Yamawaki, Florian Sicklinger, Niklas Hartman, Andrea L. Bredemeyer, Chang Jie Mick Lee, Vee Xu, , Kory J. Lavine
This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.
bioRxiv · Jul 25, 2025 · PreprintImmunology