Adam Cryar

Both terminal misfolding and polymerisation contribute to disease-relevant phenotypic changes in cell models of alpha-1-antitrypsin deficiency-associated liver disease

This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.

Laminin 111 triggers cell quiescence and long-term survival by inducing IQGAP1-mediated cytosolic scaffolding of ERK and BAD inactivation

This paper identifies Laminin 111 as a trigger for cellular quiescence and long-term survival through IQGAP1-mediated cytosolic scaffolding of ERK and BAD inactivation.

A candidate reference method for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring

This paper develops a reference method for quantifying α-synuclein in CSF using SI-traceable calibration and MRM, showing linearity across three orders of magnitude.