Konstantinos Thalassinos

This study uses single-cell proteomics to show that DNA damage causes heterogeneous and bimodal proteome responses in U2 OS cells, revealing cell-to-cell variability obscured by bulk analysis.

The paper identifies an alternatively-spliced form of CHC17 (CHC17-SAS) that compensates for the absence of CHC22 in some vertebrates, enabling GLUT4 trafficking.

This paper introduces a novel recombinant chymotrypsin (rChymoSelect) with enhanced cleavage specificity, improving proteome coverage and reducing missed cleavages in proteomics workflows.

The paper identifies how the HMD domain of Prf1 in the PAF1C complex activates HULC for H2B ubiquitination by repositioning its RING domains.

This paper shows metformin protects neurons by stabilizing rngo/DDI2, enhancing proteostasis and reducing toxicity in multiple neurodegenerative models.

This paper introduces NanoBondy, a covalent cell-surface modification technology for immune cells using NeissLock chemistry, demonstrating robust and specific ligation to CD45.

The paper shows TBK1 phosphorylates Rab7 to regulate unidirectional retrograde transport of signalling endosomes in motor neurons, linking TBK1 dysfunction to ALS-related transport impairments.

This study develops a new mass-spectrometry method to detect protein-glutathionylation, revealing its widespread distribution and dynamic role in regulating protein interactions and active site accessibility across species.

This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.

This study identifies a lncRNA, aal1, that extends lifespan in fission yeast by reducing ribosome content and protein translation, with similar effects observed in Drosophila.

This paper identifies Laminin 111 as a trigger for cellular quiescence and long-term survival through IQGAP1-mediated cytosolic scaffolding of ERK and BAD inactivation.

The paper introduces a pipeline combining AlphaFold2 and XL-MS to model protein conformations, showing improved accuracy in identifying correct structures using new scores.

The paper introduces MoDS, a score for assessing protein structure models using monolink data, and shows combining it with MNXL improves model scoring, supporting the use of monolink data in integrative structure determination.