Double knockout CRISPR screen in cancer resistance to T cell cytotoxicity
Jonathan Joon-Young Park, Adan Codina, Lupeng Ye, Stanley Z. Lam, Jianjian Guo, Paul R. Clark, Xiaoyu Zhou, Lei Peng, Sidi Chen
The paper identifies genetic interactions between cancer mutations and immune resistance genes using a CRISPR double knockout screen, revealing potential targets for existing drugs.
Journal of Hematology & Oncology · Dec 1, 2022Peer-reviewedGenomics