Histone Deacetylases (HDACs) maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and non-coding loci
Richard D. Kelly, Kristy R. Stengel, Aditya Chandru, Lyndsey C. Johnson, Scott W. Hiebert, Shaun M. Cowley
The paper shows HDACs maintain pluripotency by regulating RNA polymerase II recruitment to enhancer regions through histone acetylation and BRD4 interactions.
Genome Research · Jan 1, 2024Peer-reviewedMolecular Biology