Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes
Anna C. Love, Harshverdhan Sirohi, Felix M. Hubert, Ying-Chieh Kao, Daniel Quinnell, Tian Lan, Ryan Gappy, Marissa Sheehy, Jonathan Hsu, Adrian Lee, Liana Zangwill, Timothy Chang, Bruce Allan Palfey, Geoffrey Chang, Bradley S. Moore
This study elucidates the structural and biochemical mechanisms of cannabinoid cyclase activity in marine bacterial enzymes Clz9 and Tcz9, revealing distinct mechanisms from Cannabis cyclases and enabling stereoselective CBCA production.
Nature Chemical Biology · Jul 7, 2026Peer-reviewedBiochemistry