Tian Lan

RamiGlyph Captures Microglial Morphological Diversity and Predicts Functional States in Ischemia Reperfusion and Amyloid Pathology

Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes

This study elucidates the structural and biochemical mechanisms of cannabinoid cyclase activity in marine bacterial enzymes Clz9 and Tcz9, revealing distinct mechanisms from Cannabis cyclases and enabling stereoselective CBCA production.

A neural circuit mechanism for abstract free choice

This study investigates the neural mechanisms of abstract free choice using a delayed-response paradigm and a hierarchical attractor network model, finding that free choices involve slower responses and reduced goal-switching costs.

Endothelin-1 signaling regulates chamber-specific mouse atrial cardiomyocyte cytokinesis and polyploidy

This study shows that endothelin-1 signaling regulates chamber-specific polyploidy in mouse atrial cardiomyocytes through effects on cytokinesis.

Local translation of circular RNAs is required for synaptic activity and memory

The paper identifies local translation of circular RNAs in the prefrontal cortex of mice, revealing a micropeptide involved in synaptic activity and memory.

A mobile circular DNA element drives memory-related processes in mice

The paper identifies a brain-enriched extrachromosomal circular DNA (ecDNA) that regulates plasticity-related genes and is linked to fear memory stability in mice.

Elastase mediated white matter damage in cerebral small vessel disease: Microglia - neutrophils pas de deux

This study identifies elastase (ELANE) as a driver of white matter damage in cerebral small vessel disease, showing its role in oligodendrocyte death and proposing it as a therapeutic target.