Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
Ola Hassan, Mattia D. Pizzagalli, Owen P. Leary, John P. Zepecki, Adrianne Corseri, Laura Jinxuan Wu, Shiven Sasipalli, Daniel Lee, Lindsey Hayward, Lily H. Tran, Eduardo J. Fajardo, András Fiser, David I. Karambizi, Nikos Tapinos
This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.
Journal of Biological Chemistry · Sep 17, 2025Peer-reviewedCancer Biology