Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function
Sudha Sunil Rajderkar, Iros Barozzi, Yiwen Zhu, Rong Hu, Yanxiao Zhang, Bin Li, Y. Fukuda, Guy Kelman, Adyam Akeza, Matthew J. Blow, Quan T. Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, , Len A. Pennacchio
This study shows that deleting TAD boundaries in mice often causes molecular or developmental phenotypes, highlighting their importance for genome function.
bioRxiv · May 6, 2021 · PreprintGenomics