A single-nucleus multimodal framework reveals epigenomic priming of chemoresistant states in ovarian cancer
Yuna Landais, Juliette Bertorello, Marta Puerto, Agathe Kahn, Baptiste Simon, Amélie Roehrig, Adeline Durand, Marceau Quatredeniers, Constance Lamy, Enora Laas, Nicolas Pouget, Simon Dumas, Jean-Guillaume Féron, Virginie Fourchotte, Claire Bonneau, , Céline Vallot
This paper develops a single-nucleus multimodal framework to analyze transcriptional and histone modification landscapes in ovarian cancer, revealing epigenomic priming of chemoresistant states and its impact on treatment outcomes.
bioRxiv · Dec 8, 2025 · PreprintCancer Biology