Optimized iMAP CRISPR Perturbation Illuminates Context-Specific Functions of RNA Modification Factors
Ge Wei, Zhengyu Jing, Weikai Wang, Bo Liu, Shaoshuai Mao, Junjun Lv, Xiaoming Zhang, Dingyu Cao, Ruilin Sun, Aibing Liang, Tian Chi
The paper optimizes the iMAP CRISPR platform to reduce recombination bias, profiles RNA modification factors across mouse tissues, and identifies context-specific functions with therapeutic implications.
bioRxiv · Jul 24, 2025 · PreprintGenomics