Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy
Ahmadreza Attarpour, Misha Raffiee, Tony Xu, Jonas Osmann, Shruti B Patel, Fengqing Yu, Braedyn Au, Andrew S. Clappison, Mahdi Biparva, Rui Zhu, Ailey Crow, Barsin Eshaghi Gharagoz, Matthew W Rozak, Isabelle Aubert, JoAnne McLaurin, , Maged Goubran
This paper introduces MAPL3, a deep learning pipeline for mapping whole-brain connectomes at single-axon resolution, demonstrating its effectiveness in analyzing orbitofrontal cortex circuitry.
bioRxiv · Nov 14, 2025 · PreprintNeuroscience