Aimin Yan

Preclinical lentiviral vector-mediated hematopoietic stem and progenitor cell gene therapy corrects Pompe disease-related muscle and neurological manifestations

This study shows lentiviral HSPC gene therapy can reverse Pompe disease symptoms in mice by correcting muscle and neurological issues.

IS-Seq: a bioinformatics pipeline for integration sites analysis with comprehensive abundance quantification methods

IS-Seq is a bioinformatics pipeline that integrates UMI-based and other methods for IS abundance estimation, showing UMI provides better accuracy than sonication fragment counts in clinical scenarios.

Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative disease

This study shows genetically engineered microglia-like cells can provide therapeutic protein levels in mouse models of neurodegenerative diseases.

Distinct features of nucleolus-associated domains in mouse embryonic stem cells

The paper maps nucleolus-associated domains (NADs) in mouse embryonic stem cells, revealing developmental differences in their characteristics compared to mouse embryonic fibroblasts.

Two Contrasting Classes of Nucleolus-Associated Domains in Mouse Fibroblast Heterochromatin

The paper identifies two distinct classes of Nucleolus-Associated Domains (NADs) in mouse fibroblasts using deep sequencing and a new tool, showing differences in chromatin features and gene expression.