A novel lipid-triggered allosteric site modulates LC3-LIR receptor binding activity
Deepanshi Gahlot, Jesu Castin E, S C Mathur, Debajyoti Das, Ajit Kumar, Akanksha Arun, Chandrima Gain, Mridul Sharma, Ravi Kant Pal, Niyati Jain, Bichitra Kumar Biswal, Rajat Singh, Lipi Thukral
This study identifies a lipid-triggered allosteric site in LC3 that modulates receptor binding activity through conformational changes upon membrane engagement.
Nature Communications · Aug 28, 2026Peer-reviewedBiophysics