Real-time visualization reveals Mycobacterium tuberculosis ESAT-6 disrupts phagosome via fibril-mediated vesiculation
Debraj Koiri, Mintu Nandi, P M Abik Hameem, Aher Jayesh Bhausaheb, Geetanjali Meher, Assirbad Behura, Akhil Kumar, Vineet Choudhary, Sandeep Choubey, Mohammed Saleem
This study reveals how ESAT-6 disrupts the phagosomal membrane through fibril-mediated vesiculation, leading to host cell death and promoting Mtb infection.
bioRxiv · Apr 19, 2024 · PreprintBiophysics