Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid Leukemia
Evie Rigby, Francesca Fasanella Masci, Akshara Narayanan, Elżbieta Kania, John A. Harris, Jamie J.L. Williams, Binghua Zhang, Lijun Liu, Laura Richmond, Fengtao Zhou, Ke Ding, Ruaidhrı́ J. Carmody, Patrick A. Eyers, Karen Keeshan
This study identifies TRIB2 as a therapeutic target in AML by demonstrating that its degradation via PROTACs and small molecules can reverse chemoresistance and enhance chemotherapy efficacy.
Biochemical Journal · Mar 13, 2026Peer-reviewedCancer Biology