Supplementation via DAF-16 and pnk-1 driven pantothenate-coenzyme A flux improves disease related stress resistance in C. elegans
Steffi M Jonk, Alan Nicol, Alex Braun, Wenry Wang, James R. Tribble, Peter Swoboda, Pete A. Williams
This study shows that pantothenate supplementation improves stress resistance and extends lifespan in C. elegans by enhancing coenzyme A metabolism through DAF-16 and pnk-1 pathways.
bioRxiv · Jul 13, 2026 · PreprintNeuroscience