Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290
Christopher Greaves, William E. Martenis, Shawn Dwayne Nelson, Jon M. Madison, Adam Skepner, David Báez-Nieto, Katherine J. Stalnaker, Evan P. Lebois, Arthur J. Campbell, Katie Pelham, Mihaela Magdei, Alex Guletsky, Karen Perez de Arce, Yanling Zhang, Florence F. Wagner, , Sean P. Moran
This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.
ACS Chemical Neuroscience · Oct 29, 2026Peer-reviewedPharmacology & Toxicology