Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling
Hae Ryong Kwon, Alex Rackley, Lorin E. Olson
This study identifies STAT5-IGF1 signaling as a pathway driven by constitutive PDGFRb activation that causes connective tissue overgrowth in mice, with implications for human disease.
bioRxiv · Aug 29, 2026 · PreprintGenetics