A simple circuit to sustain intact tumor microenvironments for complex drug interrogations
Amber Leila Sarvestani, Samantha M. Ruff, Kirsten Remmert, Martha E. Teke, Emily A. Verbus, Areeba Saif, Marcial Garmendia‐Cedillos, Alex Rossi, Ashley Rainey, Krystle J. Nomie, Surajit Sinha, Michael M. Wach, Carrie Ryan, Stephanie N. Gregory, Priyanka Desai, , Jonathan Matthew Hernandez
The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.
bioRxiv · Oct 26, 2025 · PreprintCancer Biology