Alexander Bagaev

Across 7,174 multi-platform lymphoma transcriptomes, only surrogate variable analysis and feature-specific quantile normalization corrected batch effects while keeping subtype and normal B-cell differences; top-scoring MNN erased biomarker correlations.

Helenus separates malignant and microenvironment gene expression from bulk RNA-seq to improve biomarker interpretation in cancer.

The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

This study identifies high-quality neoantigens in follicular lymphoma patients using WES and RNA-Seq, and initiates a clinical trial of personalized neoantigen vaccines combined with PD-1 blockade.

This study maps human hematopoiesis at single-cell resolution, revealing aging-associated topographic remodeling in bone marrow.