J-domain proteins bridge the PKL and ATRX complex to transcription factors to fine-tune gene expression via H3.3 deposition
Shuya Wang, Colette Lafontaine Picard, Zhongshou Wu, Yan He, Alexander Barinsky, Evan K. Lin, Russell Chuang, Lu Li, Jihui Sha, James Wohlschlegel, Suhua Feng, Steven E. Jacobsen
The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.
bioRxiv · Aug 26, 2026 · PreprintPlant Biology