Evan K. Lin

The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.

The paper shows that multiple redundant mechanisms account for most gene silencing downstream of DNA methylation, with loss of these pathways causing widespread derepression and genomic changes.

The paper shows CDCA7A and CDCA7B maintain CG methylation in centromeric heterochromatin by remodeling H1-containing nucleosomes, with H1 having an inhibitory role.

This study identifies MBD2 as a methyl reader that silences transposable elements during male gametogenesis by acting downstream of DNA methylation.

The paper uses single-nucleus RNA-seq to show that MBD5, MBD6, and SILENZIO are critical for TE silencing in pollen vegetative cells during epigenetic reprogramming.