Enhancing tandem MS sensitivity and peptide identification via ion pre-accumulation in an Orbitrap mass spectrometer
Florian Harking, Ulises H. Guzmán, Julia Kraegenbring, Hamish I. Stewart, Konstantin Aizikov, Heiner Koch, Kyle L. Fort, Alexander Harder, Jesper Velgaard Olsen
This paper introduces a new scanning strategy called pre-accumulation to enhance ion utilization and sensitivity in Orbitrap mass spectrometers, improving peptide and protein identification in high-throughput proteomics.
Journal of Proteome Research · Jun 30, 2025Peer-reviewedBiochemistry