Author

Alexander Schramm

Essen University Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Barbara M. GrüneriD· 3 shared Christoph PlassiD· 2 shared Kathleen Schlüter· 2 shared Madeleine DorschiD· 2 shared Maria Llamazares PradaiD· 2 shared Mei-Ju May CheniD· 2 shared Patricia Munteanu· 2 shared Albert Fradera-SolaiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

Barbara M. GrünerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer

Madeleine Dorsch, Felix E.G. Beaudry, Anna K. Baginska, Nancy Meyer, Anne Petzold, Peihua Zhao, Belen Otero-Carrasco, Kazeera Aliar, Sebastian Urban, Julia Zummack, Jiwon Jung, Johanna Maria Hölken, Ningjun Duan, Laura Godfrey, Mei-Ju May Chen, , Barbara M. Grüner

This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.

bioRxiv · Oct 8, 2026 · PreprintCancer Biology

Artesunate Exploits Glutathione-Dependent Redox Vulnerability in Metastatic Lung Adenocarcinoma

Patricia Munteanu, Sophia Neuhaus, Paula Feldt, Vahan Serobyan, Anna Baginska, José Pedro Friedmann Angeli, Jürgen Becker, Alexander Schramm, Barbara M. Grüner

This study identifies artesunate as a drug that targets redox vulnerabilities in metastatic lung adenocarcinoma by exploiting glutathione-dependent mechanisms.

bioRxiv · Oct 7, 2026 · PreprintCancer Biology

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano-Sanchez, Dung-Chi Wu, Nan Zhang, Ofir Griess, Luc Husemann, Fabian Bradic, Joseph Cornick, Nima Esmaeelpour, Oliver Mücke, Riccardo Moro, Katherine Kelly, Sara Chocarro, , Maria Llamazares Prada

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

bioRxiv · Jun 5, 2026 · PreprintCancer Biology