Author
University Health NetworkORCID 0000-0003-1499-1020Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Madeleine Dorsch, Felix E.G. Beaudry, Anna K. Baginska…·Barbara M. Grüner
This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.
Kerenza Cheng, Kazeera Aliar, Roozbeh Manshaei…·Sarah Sabatinos
The paper models DNA replication fork stability using chromatin fiber analysis and the R-ODD-BLOBS program, showing changes in fork length and protein localization in different genetic backgrounds.
Meghan M. Capeling, Bob Chen, Kazeera Aliar…·Michelle B. Chen
The paper builds a dictionary of human intestinal organoid responses to 81 secreted niche factors using scRNA-seq, mapping perturbations and identifying cell type-specific pathways in an IBD context.
Pirashaanthy Tharmapalan, Matthew Waas, Curtis W. McCloskey…·Rama Khokha
The paper identifies PR-expressing basal cells and PR-primed progenitors, redefining mammary epithelial hierarchy and challenging existing models of breast biology and cancer.
Lukas Klein, Mengyu Tu, Niklas Krebs…·Shiv K. Singh
The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.
Curtis W. McCloskey, Bowen Zhang, Matthew Waas…·Rama Khokha
This study identifies FABP7 progenitors as a targetable metabolic root in BRCA1 breast cancer, showing their dysregulation and potential inhibition via fatty acid metabolism disruption.