Alexia Morales

Positive cooperativity between RAS-binding and cysteine-rich domains regulates RAF membrane binding kinetics via lateral rebinding

The paper shows how RAF's RBD and CRD domains work together to regulate its membrane binding through lateral rebinding, enhancing signaling specificity in RAS nanoclusters.

Quantitative Membrane Binding Assays Reveal an Inhibitory Role for the BRAF-Specific Region in CRD and Lipid Interaction

The paper identifies the BRAF-specific region (BSR) as an inhibitory module that reduces CRD lipid binding, with implications for BRAF membrane dynamics and therapeutic targeting.