Mutant Isocitrate Dehydrogenase 1 Alters Extracellular Vesicle Secretion and Cargo Composition in Cellular Models
Grace Chao, Ashley V Schwartz, Rachel Hobbs, Mikella Robinson, Bryn Baxter, Angelica M. Riestra, Sevin Turcan, Uduak Z. George, Ingrid R. Niesman, Christal D. Sohl
This study shows mutant IDH1 increases sEV secretion and alters their cargo composition in glioma and chondrosarcoma cells, with D2HG packaged into sEVs and cell-type-specific cargo remodeling.
bioRxiv · Nov 6, 2026 · PreprintCancer Biology