Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis
Kaelan R. Sullivan, Alicia Ravens, Eric de Hoog, Alicia Walker, Tessa R Kilberg, Sevnur Kömürlü Keceli, Jenifer Einstein, Mitali Tyagi, Tom Kicmal, Michael P. Hantak, Tate Shepherd, Alyson R. Stewart, Kenneth Lyon, Adarsh Dharan, Balázs Fábián, , Jason D. Shepherd
This study shows Arc EVs mediate intercellular synaptic plasticity through IRSp53-dependent biogenesis, leading to loss of surface AMPA receptors in neighboring dendrites.
bioRxiv · Jan 30, 2024 · PreprintNeuroscience