Androgen depletion increases sensitivity to effort-related costs and alters mesoaccumbal circuit function in male mice
Sara R. Westbrook, Qing Wang, Allison L. Jensen, Courtney M. Klappenbach, Katy Touretsky, Kristen M. Delevich
This study shows that androgen depletion in male mice increases sensitivity to effort costs and alters mesoaccumbal circuit function, with distinct effects depending on the timing of hormone loss.
bioRxiv · Jun 10, 2026 · PreprintNeuroscience