Cell-type specific induction of cyclo-oxygenase-2 in layer II/III prefrontal cortical neurons mediates stress-induced anxiety phenotypes in mice.
Robert J. Fenster, Kenneth M. McCullough, Sergey Naumenko, Andrew Thompson, Claudia Klengel, Allison Rodgers, Joy Otten, Dan Shu, Niki Harris, Torsten Klengel, Kerry James Ressler
This study identifies Ptgs2 as a stress-induced gene in specific prefrontal cortical neurons that mediates anxiety-like behaviors in mice.
bioRxiv · Oct 10, 2021 · PreprintNeuroscience