Effects Of Lymphocyte Trafficking on Antiretroviral Drug Distribution within the Lymph Node
Sobia Anam, Michael Donzanti, Allyson Dang, Sasan Paryad-Zanjani, Michael J Piovoso, Jason P Gleghorn, Ryan Zurakowski
This study shows that blocking lymphocyte entry into lymph nodes increases intracellular drug concentration for some antiretroviral drugs, but not others, due to changes in extracellular fluid volume.
bioRxiv · Nov 3, 2026 · PreprintPharmacology & Toxicology