G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway
Esther Liu, Matthew Wright, Andrew O. Kearney, Tiffany N. Caza, Johnson Y. Yang, Valerie Garcia, Amal Dadi, Shuta Ishibe, Navdeep S. Chandel, Hanrui Zhang, Edward Benjamin Thorp, Jennie J. Lin
This study shows G1 and G2 APOL1 variants increase macrophage inflammation and lipid accumulation via the polyamine pathway, which can be inhibited by DFMO.
bioRxiv · Jun 6, 2025 · PreprintCell Biology