HIV-1 controllers possess a unique CD8+ T-cell activation phenotype and loss of control is associated with increased expression of exhaustion markers
Amber D. Jones, Zachary Capriotti, Erin Santos, Angel M. Lin, Rachel Van Duyne, Stephen M. Smith, Zachary A. Klase
The paper examines CD8+ T-cell exhaustion in HIV-1 controllers and finds that loss of control correlates with increased exhaustion markers, which can be reversed by immune checkpoint blockade.
PLoS ONE · Aug 28, 2025Peer-reviewedImmunology