Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster
Sarah B. Marion, Katrina Focht, Iman Hamid, Edwin S. Iversen, Hannah John, Brenda Manzano‐Winkler, Amber Navarra, Saniya Pangare, Mehrnaz Zarei, Mohamed A. F. Noor
This study identifies transposable element insertions as a major cause of recessive lethality in Drosophila melanogaster, suggesting they drive lethal mutation frequencies through repeated invasions and suppression.
bioRxiv · Oct 16, 2025 · PreprintEvolutionary Biology