Disruption of Pre-Bötzinger Complex neuropeptidergic tonality controls fear and metabolic response
Sanutha Shetty, Amir Farmanbar, Pamela Toh, Ramazan Yildiz, YoungUk Jang, Samuel J. Duesman, Aidan Warnock, Diego Espinoza, Sarah Stanley, Prashant Rajbhandari, Abha Karki Rajbhandari
This paper identifies a brainstem circuit involving PAC1R in preBotC neurons that links stress responses to metabolic regulation, showing its role in fear, respiration, and energy expenditure.
bioRxiv · Jan 2, 2026 · PreprintNeuroscience