Spatial remodeling of the thymic stroma with age disrupts niches for T cell selection and tolerance
Andreas Tarcevski, Fatima Dhalla, Joshua W. Moore, Saulius Žuklys, Anja Kusch, Liliana Tchernev, Joshua Grier, Stefano Maio, Amir Khan, Thomas Barthlott, Mary E. Deadman, Adam E. Handel, Helen Mary Byrne, Georg A. Holländer
This study maps spatial changes in the aging mouse thymus, revealing stromal reorganization that disrupts T cell selection and tolerance.
bioRxiv · Aug 5, 2026 · PreprintImmunology