Author

Amit Kumar Singh

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Microbiology· 3 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Hridayesh PrakashiD· 3 shared Niharika Sharma· 3 shared Vijay HaddaiD· 3 shared Abhishek Kumar· 2 shared Lalit Kumar SinghiD· 2 shared Rahul SharmaiD· 2 shared Amit MisraiD· 1 shared Anjaneya AyanuriD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

Hridayesh PrakashORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sphingosine-1-Phosphate Restrains Foamy Macrophage Formation and Modulates Inflammation in Multidrug-Resistant Tuberculosis

Abhishek Kumar, Niharika Sharma, Lalit Kumar Singh, Vijay Hadda, Amit Kumar Singh, Hridayesh Prakash

This study investigates the role of sphingosine-1-phosphate (S1P) in modulating foamy macrophage formation and inflammation in multidrug-resistant tuberculosis (MDR-TB).

bioRxiv · Oct 20, 2026 · PreprintImmunology

L-Serine and Palmitoyl CoA control Mycobacterial infection by tweaking protective immune response: A potential host directed therapy for tuberculosis

Niharika Sharma, Rahul Sharma, Abhishek Kumar, Lalit Kumar Singh, Anjaneya Ayanur, Vijay Hadda, Amit Kumar Singh, Hridayesh Prakash

This study investigates the role of L-Serine and palmitoyl CoA in enhancing the immune response against Mycobacterium tuberculosis, showing improved bacterial clearance and tissue recovery in murine models.

bioRxiv · Sep 3, 2026 · PreprintMicrobiology

MTB-LysB1: A Novel Endolysin Against Multidrug-resistant Mycobacterium tuberculosis

Ritu Arora, Kandasamy Eniyan, Jyoti Rani, Amit Kumar Singh, Urmi Bajpai

This paper characterizes MTB-LysB1, a novel endolysin from a mycobacteriophage, showing activity against drug-susceptible and multidrug-resistant M. tuberculosis strains and additive effects with TB drugs.

bioRxiv · Jul 13, 2026 · PreprintMicrobiology

Mycobacteriophage D29-Derived LysB Enhances Anti-Tubercular Therapy in Experimental Pulmonary Tuberculosis

Sunil Kumar Raman, Rahul Sharma, Rutuja Gangakhedkar, Priyamvada Nath, Amit Misra, Vikas Kumar Jain, Amit Kumar Singh

This study shows that intranasal administration of D29 LysB enhances the effectiveness of standard antitubercular therapy in murine and guinea pig models of tuberculosis by reducing bacterial load and improving tissue pathology.

bioRxiv · May 29, 2026 · PreprintMicrobiology

ATLS2021-PA (A Sphingolipid mimetic): Upcoming Host Directed Therapy for Acute and MDR Tuberculosis

Niharika Sharma, Rahul Sharma, Vijay Hadda, Amit Kumar Singh, Hridayesh Prakash

This paper demonstrates that ATLS2021 enhances sphingolipid levels and improves anti-tubercular efficacy, including sensitizing MDR TB to Rifampicin and inducing immunogenic responses.

bioRxiv · Mar 17, 2025 · PreprintPharmacology & Toxicology