Amy Gilson

Transient protein-protein interactions perturb E.coli metabolome and cause gene dosage toxicity

This study shows that overexpression of DHFR in E. coli causes metabolic imbalance and gene dosage toxicity through interactions with metabolic enzymes, while orthologous DHFRs from other species show reduced effects due to evolutionary divergence.

Benchmarking inverse statistical approaches for protein structure and design with exactly solvable models

This paper benchmarks inverse statistical methods for protein structure and design using exactly solvable lattice protein models, showing their ability to capture both positive and negative design principles.