Sanchari Bhattacharyya

This study shows that overexpression of DHFR in E. coli causes metabolic imbalance and gene dosage toxicity through interactions with metabolic enzymes, while orthologous DHFRs from other species show reduced effects due to evolutionary divergence.

This study shows that protein homeostasis limits the functional integration of horizontally transferred genes in bacteria by reducing the abundance of foreign proteins, and that this barrier can be overcome through evolutionary adaptation.