Mycobacterium tuberculosis inactivates host oxysterols to impair macrophage cholesterol homeostasis
Andrew Roth, Mohsen Ali Asgari, Pallavi Chandra, Jalalah Muhammad, Amy Lopez, Sourav Bhattacharya, Isabelle A. Williams, Brian T. Edelson, Charles W. Goss, Dmitri Ivanovich Kotov, Mingxing Qian, Douglas F. Covey, 蒋巡天, William James Griffiths, Yuqin Wang, Jennifer A. Philips
This study identifies Mtb's enzymatic inactivation of host oxysterols as a mechanism to disrupt macrophage cholesterol homeostasis and generate treatment-responsive metabolic signatures in TB.
bioRxiv · Oct 5, 2026 · PreprintMicrobiology