Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis
Cong Liu, Z. Audrey Wang, Edward B. Prideaux, David L. Boyle, Katherine Nguyen, Vlad Tsaltskan, Amy Westermann, Andrea E. Ochoa, Kevin D. Deane, Marie L. Feser, Mary Kristen Demoruelle, Kristine A. Kuhn, Vernon Michael Holers, Fan Zhang, Ashley G. Asamoah, , Wei Wang
The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.
bioRxiv · Feb 8, 2025 · PreprintSystems Biology