Natural variation in transplacental transfer efficiency exposes distinct transcriptional network architectures of PFAS effects on birth weight and gestational age
Sean T. Bresnahan, Hannah E. J. Yong, Maggie G Drelichman, Soraya N Campbell, Ance E Trapse, Gabriel R. Romo, Christopher M Cellini, S. C. Valbuena Lopez, Jerry Kok Yen Chan, Shiao-yng Chan, Elana R. Elkin, Arjun Bhattacharya, Jonathan Yinhao Huang
The paper shows PFAS affect birth weight and gestational age through distinct transcriptional network architectures, with network position, not fold-change, determining mediator importance.
bioRxiv · Mar 25, 2026 · PreprintDevelopmental Biology