Jonathan Yinhao Huang

ICONIC is an R package that integrates instrumental variable and negative-control methods for causal inference in multi-omic studies, offering diagnostics and benchmarks for mediation analysis.

The paper uses long-read RNA-seq to create a comprehensive placental transcriptome reference, revealing high transcriptional complexity and identifying novel isoforms associated with metabolic and endocrine functions in gestational diabetes.

The paper shows PFAS affect birth weight and gestational age through distinct transcriptional network architectures, with network position, not fold-change, determining mediator importance.