Retinol Binding Protein 4 reactivates latent HIV-1 via the JAK/STAT5 and JNK pathways
Chiara Pastorio, Khumoekae Richard, Manuel Hayn, Lennart Koepke, Andrea Preising, Nico Preising, Ludger Ständker, Matthew G. Fair, Jessicamarie Morris, Emmanouil Papasavvas, Honghong Sun, Armando Rodríguez, Karam Mounzer, Sebastian Wiese, Pablo Tebas, , Frank Kirchhoff
This study identifies Retinol Binding Protein 4 (RBP4) as a natural activator of latent HIV-1 through JAK/STAT5 and JNK pathways, offering a new strategy for reactivating viral reservoirs.
bioRxiv · Feb 26, 2025 · PreprintImmunology