Author

Andreas Hofmann

Novartis Institutes for BioMedical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Amandine Rietsch· 1 shared Andrew I. MorrisoniD· 1 shared Benedikt GoretzkiiD· 1 shared Christian N. ParkeriD· 1 shared Damien Begue· 1 shared Danilo GueriniiD· 1 shared Débora BonenfantiD· 1 shared Delphine Jeanpierre· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Amandine Rietsch

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2 papers

Recent·Most cited

A novel HERC4-dependent glue degrader targeting STING

Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrné, Sandra Kapps, Susan Roest, Débora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, , Danilo Guerini

This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.

bioRxiv · Feb 8, 2023 · PreprintMolecular Biology

Environment driven conformational changes modulate H-NS DNA bridging activity

Ramon A. van der Valk, Jocelyne Vreede, Geri F. Moolenaar, Andreas Hofmann, Nora Goosen, Remus T. Dame

This study shows that environmental factors and interaction partners modulate H-NS DNA bridging activity through conformational changes.

bioRxiv · Dec 30, 2016 · PreprintBiochemistry